Crystallization & Isolation

High-Purity Isolate Production — 7-Stage Controlled Workflow engineered for laboratory-grade purity and consistent particle specifications.

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High-Purity Isolate Production

STIX's crystallization and isolation process follows a rigorous 7-stage workflow designed to achieve laboratory-grade purity and consistent particle specifications. Every stage is conducted within a closed, controlled environment — minimizing contamination risk, maximizing solvent removal efficiency, and ensuring lot-to-lot reproducibility.

The result is an isolate product that meets stringent, documented purity specifications, with full analytical characterization and batch documentation suitable for regulatory submission.

Isolation

Crystallization & Isolation

Stix operates a dedicated, GMP-aligned crystallization and isolation facility located in a fully separated wing of the building to maintain controlled material flow, environmental segregation, and compliance with pharmaceutical-oriented quality principles. All isolate production is performed using high-purity dryer filter systems manufactured by GL Filtration, including both the FD875 and FD1000 units.

Our multi-stage workflow dissolves distillate into high-purity heptane, initiates controlled crystal growth in jacketed crystallization reactors, then washes, dries, centrifuges, and finishes the isolate in Cascade Sciences vacuum ovens before milling, sieving, and final QC testing — ensuring consistent particle size and batch uniformity with minimal handling.

Every stage is tracked through Stix’s custom-built track and trace software, recording material movement, batch parameters, yield performance, equipment utilization, and process deviations. This integrated platform enables high-purity, laboratory-grade cannabinoid isolates with exceptional consistency.

7-Stage Workflow

From Distillate to Final Isolate

Stage 1 — Dissolution

Distillate dissolved in high-purity heptane under defined temperature and agitation parameters to achieve a homogeneous feed solution.

Stage 2 — Crystallization Reactors

Jacketed reactors with controlled cooling and agitation initiate nucleation and direct crystal growth to target particle size and morphology.

Stage 3 — GL Filtration Dryer-Filter

FD875 & FD1000 units perform precision wash cycles to remove residual solvents and co-crystallized impurities from the crystal cake.

Stage 4 — Sealed Drying

Primary drying within the same sealed system minimizes handling, reduces contamination risk, and maintains product integrity.

Stage 5 — Industrial Centrifuge

Additional solvent removal for enhanced purity — the centrifuge achieves tighter residual solvent specs before final drying.

Stage 6 — Cascade Sciences Vacuum Ovens

Final drying under controlled vacuum and temperature achieves required residual-solvent specifications for regulatory compliance.

Stage 7 — Milling & Final QC

Milled, sieved, and tested for consistent particle size and batch uniformity. Full analytical release testing before any product ships.

Request Isolate Specifications & COA

Full analytical packages — including purity, residual solvents, heavy metals, pesticides, and particle size — available for all isolate products.